منابع مشابه
Nanoporesize affects complement activation.
In the present study, we have shown the vast importance of biomaterial nanotexture when evaluating inflammatory response. For the first time in an in vitro whole blood system, we have proven that a small increase in nanoporesize, specifically 180 nm (from 20 to 200 nm), has a huge effect on the complement system. The study was done using nanoporous aluminiumoxide, a material that previously has...
متن کاملInfluence of nanoporesize on platelet adhesion and activation.
In this study we have evaluated the influence of biomaterial nano-topography on platelet adhesion and activation. Nano-porous alumina membranes with pore diameters of 20 and 200 nm were incubated with whole blood and platelet rich plasma. Platelet number, adhesion and activation were determined by using a coulter hematology analyzer, scanning electron microscopy, immunocytochemical staining in ...
متن کاملNon-specific adsorption of complement proteins affects complement activation pathways of gold nanomaterials.
The complement system is a key humoral component of innate immunity, serving as the first line of defense against intruders, including foreign synthetic nanomaterials. Although gold nanomaterials (AuNMs) are widely used in nanomedicine, their immunological response is not well understood. Using AuNMs of three shapes commonly used in biomedical applications: spherical gold nanoparticles, gold na...
متن کاملComplement Activation
The complement system is the most important biochemical cascade in the blood for the recognition, opsonization, and elimination of foreign materials. To date, the leading causes of death in the United States include cancer, cardiovascular and neurodegenerative diseases, and diabetes. New treatments are urgently needed to treat these devastating diseases and nanotechnology potentially provides n...
متن کاملActivation of Complement
Activation of the complement system by IgA has been a controversial subject since Ishizaka et al. (1) and South et al. (2) observed that C1 was not fixed by IgA. Lack of complement activation has also been inferred from reports that secretory IgA antibodies were unable to opsonize or promote bacterial killing in the presence of complement (3 6). On the other hand, there is evidence that some co...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2008
ISSN: 1549-3296,1552-4965
DOI: 10.1002/jbm.a.31818